研究論文（主要なものは太字）
66) H. Izawa,* F. Yasufuku, S. Ifuku, H. Saimoto, T. Matsui, K. Morihashi,
M. Sumita “Unique Photophysical Properties of 1,8-Naphthalimide Derivatives:
Generation of Semi-Stable Radical Anion Species by Photo-Induced Electron
Transfer from a Carboxy Group” ACS Omega, 6, 13456–13465 (2021).(Highlighted as Supplementary Cover Art)
65) H. Izawa,* Y. Toyoshima, M. Morimoto, H. Saimoto, S. Ifuku “Surface
wrinkles induced on oriented chitosan films via horseradish peroxidase-catalyzed
reaction and drying” Chemistry Letters, 50, 252–255 (2021).
64) H. Izawa,* H. Kajimoto, M. Morimoto, H. Saimoto, S. Ifuku “Honeycomb-like
porous chitosan films prepared via phase transition of poly(N-isopropylacrylamide)
during water evaporation at ambient condition” RSC Advances, 10, 19730–19735
(2020).
63) Y. F. Aklog, Shinsuke Ifuku*, H. Izawa, H. Saimoto, M. Morimoto “Effect
of grinder pretreatment for easy disintegration of chitin into nanofiber”
Polymer, 17, 5037–5041 (2020).
62) H. Izawa,* M. Kinai, S. Nishin, S. Ifuku, M. Morimoto, H. Saimoto*
“Guanidinylation of chitooligosaccharides involving internal cyclization
of the guanidino group on the reducing end and effect of guanidinylation
on protein binding ability” Biomolecules, 9, 259–268 (2019).
61）H. Izawa,* Y. Miyazaki, T. Yonemura, N. Ito, Y. Okamoto, S. Ifuku, M.
Morimoto, H. Saimoto* “Polysaccharide-based wrinkled surfaces induced by
polyion complex skin layers upon drying” Polymer Journal, 51, 675–683 (2019).(Selected as a Featured Article、Polymer Journal論文賞-日本ゼオン賞)
60) H. Izawa,* M. Kinai, S. Nishin, S. Ifuku, M. Morimoto, H. Saimoto*
“Guanidinylated chitosan inspired by arginine-rich cell penetrating peptides”
International Journal of Biological Macromolecules, 125, 901–905 (2019).
59) H. Izawa,* M. Wada, S. Nishino, M. Sumita, T. Fujita, K. Morihashi,
S. Ifuku, M. Morimoto, H. Saimoto* “Discrimination of anionic polysaccharides
via monomer-excimer switching and photo-induced colorimetric reaction of
1-methyl-3-(N-(1,8-naphthalimidyl)ethyl) imidazolium” Bulletin of the Chemical
Society of Japan, 91, 1220–1225 (2018).
58) H. Izawa,* N. Okuda, T. Yonemura, K. Kuroda, K. Ochi, S. Ifuku, M.
Morimoto, H. Saimoto, M. Noda, K. Azuma,* N. Ito* “Application of Bio-Based
Wrinkled Surfaces as Cell Culture Scaffolds” Colloids and Interfaces, 2,
15–25 (2018).
57) T. Otsuka, M. Sumita, H. Izawa, K. Morihashi, “Theoretical study on photo-induced processes of 1-methyl-3-(N-(1,8-naphthalimidyl)ethyl)imidazolium
halide species: an application of constrained density functional theory”
Physical Chemistry Chemical Physics, 20, 3911-3917 (2018). (Selected as Back Cover)
56)H. Izawa,* Y. Dote, N. Okuda, S. Ifuku, M. Morimoto, H. Saimoto* “Wood-mimetic
skins prepared using horseradish peroxidase catalysis to induce surface
wrinkling of chitosan film upon drying” Carbohydrate Polymers, 173, 519–525
(2017).
55) Y. F. Aklog, T. Nagae, H. Izawa, H. Saimoto, Shinsuke Ifuku* “Effect of grinder pretreatment for easy
disintegration of chitin into nanofiber” Journal of Nanoscience and Nanotechnology,
17, 5037–5041 (2017).
54) R. Koizumi, K. Azuma,* H. Izawa, M. Morimoto, K. Ochi, T. Tsuka, T. Imagawa, T. Osaki, N. Ito, Y. Okamoto,
H. Saimoto, S. Ifuku* “Oral administration of surface-deacetylated chitin
nanofibers and chitosan inhibit 5-fluorouracil-induced intestinal mucositis
in mice” ” International Journal of Molecular Sciences, 18, 279-289 (2017).
53)H. Izawa,* N. Okuda, A. Moriyama, Y. Miyazaki, S. Ifuku, M. Morimoto, H. Saimoto*
“Biobased Wrinkled Surfaces Induced by Wood Mimetic Skins Upon Drying:
Effect of Mechanical Properties on Wrinkle Morphology” Langmuir, 32, 12799–12804
(2016).
52) Y. Daimon, N. Kamei, K. Kawakami,* M. Takeda-Morishita, H. Izawa, Y. Takechi-Haraya, H. Saito, H, Sakai, M. Abe, K. Ariga “Dependence of
intestinal absorption profile of insulin on carrier morphology composed
of β-cyclodextrin-grafted chitosan” Molecular Pharmatics, 16, 4034–4042
(2016).
51) Y. F. Aklog, T. Nagae, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku* “Preparation of chitin nanofibers
by surface esterification of chitin with maleic anhydride and mechanical
treatment” Carbohydrate Polymers, 153, 55–59 (2016).
50) T. Otsuka, M. Sumita,* H. Izawa, K. Morihashi “Intermolecular electron transfer states of 1-methyl-3-(N-(1,
8-naphthalimidyl) ethyl) imidazolium iodide obtained by constrained density
functional theory” Physical Chemistry Chemical Physics, 18, 17795-17798
(2016). (Selected as Back Cover)
49)H. Izawa,* Y. Miyazaki, S. Ifuku, M. Morimoto, H. Saimoto* “Fully bio-based oligophenolic
nanoparticle prepared by horseradish peroxidase-catalyzed polymerization”
Chemistry Letters, 45, 631–633 (2016).
48) R. Izumi, K. Azuma, H. Izawa, M. Morimoto, M. Nagashima, T. Osaki, T. Tsuka, T. Imagawa, N. Ito, Y.
Okamoto, H. Saimoto, S. Ifukua “Chitin nanofibrils suppress skin inflammation
in atopicdermatitis-like skin lesions in NC/Nga mice” Carbohydrate Polymers,
146, 320–327 (2016).
47)H. Izawa,* K. Yamamoto, S. Yoshihashi, S. Ifuku, M. Morimoto, H. Saimoto “Facile
preparation of cyclodextrin-grafted chitosans and their conversion into
nanoparticles for anticancer drug delivery system” Polymer Journal, 48,
203-207 (2016).
46) M. Kawata, K. Azuma, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku, “Biomineralization of calcium phosphate
crystals on chitin nanofiber hydrogel for bone regeneration material” Carbohydrate
Polymers, 136, 964-969 (2016).
45) M. Egusa, R. Iwamoto, H. Izawa, M. Morimoto, H.,Saimoto, H. Kaminaka, S. Ifuku “Characterization of chitosan
nanofiber sheets for antifungal application” International Journal of Molecular
Sciences, 16, 26202-26210 (2015).
44)H. Izawa,* N. Okuda, S. Ifuku, M. Morimoto, H. Saimoto,* O. J. Rojas “Bio-based
wrinkled surfaces harnessed from biological design principles of wood and
peroxidase activity” ChemSusChem, 8, 3892–3896 (2015).
43) K. Azuma, R. Izumi, M. Kawata, T. Nagae, T. Osaki, Y. Murahata, T.
Tsuka, T. Imagawa, N. Ito, Y. Okamoto, M. Morimoto, H. Izawa, H. Saimoto, S. Ifuku* “Effects of oral administration of chitin nanofiber
on plasma metabolites and gut microorganisms” International Journal of
Molecular Sciences, 16, 21931-21949 (2015).
42) K. Azuma, T. Nagae, T. Nagai, H. Izawa, M. Morimoto, Y. Murahata, T. Osaki, T. Tsuka, T. Imagawa, N. Ito, Y.
Okamoto, H. Saimoto, S. Ifuku* “Effects of surface-deacetylated chitin
nanofibers in an experimental model of hypercholesterolemia” International
Journal of Molecular Sciences, 16, 17445-17455 (2015).
41) S. Ifuku,* T. Urakami, H. Izawa, M. Morimoto, H. Saimoto “Preparation of a protein-chitin nanofiber complex
from crab shells and its application as a reinforcement filler or substrate
for biomineralization” RSC Advances, 5, 64196-64201 (2015).
40) S. Ifuku,* H. Maeta, H. Izawa, M. Morimoto, H. Saimoto ‘’Preparation of Polybenzoxazole Nanofibers by
a Downsizing Process” RSC Advances, 5, 35307-35310 (2015).
39) A. K. Dutta, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku* “A green approach to endow chitin
nanofiber with fluorescence” Journal of Chitin and Chitosan Science, 3,
53-56 (2015).
38)H. Izawa,* S. Nishino, M. Sumita, K. Morihashi, S. Ifuku, M. Morimoto, H. Saimoto
“A novel 1,8-Naphthalimide derivative with an open space for an anion:
Unique fluorescence behaviour depending on the binding anion’s electrophilic
property” Chemical Communications, 51, 8596-8599 (2015).(Selected as Back Cover)
37) Y, Takechi-Haraya, K. Tanaka, K. Tsuji, Y. Asami, H. Izawa, A. Shigenaga, A. Otaka, H. Saito, K. Kawakami* “Molecular complex composed
of beta‑cyclodextrin-grafted chitosan and pH-sensitive amphipathic peptide
for enhancing cellular cholesterol efflux under acidic pH” Bioconjugate
chemistry, 26, 572−581 (2015).
36) R. Izumi, S. Komada, K. Ochi, L. Karasawa, T. Osaki, Y. Murahata, T.
Tsuka, T. Imagawa, N. Itoh, Y. Okamoto, H. Izawa, M. Morimoto, H. Saimoto, K. Azuma, S. Ifuku* “Favorable effects of superficially
deacetylated chitin nanofibrils on the wound healing process” Carbohydrate
Polymers, 123, 461-467 (2015).
35) Shinsuke Ifuku,* Taishi Hori, H. Izawa, M. Morimoto, H. Saimoto “Preparation of zwitterionically charged nanocrystals
by surface TEMPO-mediated oxidation and partial deacetylation of alpha-chitin”
Carbohydrate Polymers, 122, 1-4 (2015).
34) K. Azuma, M. Nishihara, H. Shimizu, Y. Itou, O. Takashima, T. Osaki,
N. Itoh, T. Imagawa, Y. Murahata, T. Tsuka, H. Izawa, S. Ifuku, S. Minami, H. Saimoto, Y. Okamoto, M. Morimoto* “Biological
adhesive based on carboxymethyl chitin derivatives and chitin nanofibers”
Biomaterials, 42, 20-29 (2015).
33) Y. F. Aklog, A. K. Dutta, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku* “Preparation of chitosan nanofibers
from completely deacetylated chitosan powder by a downsizing process” International
Journal of Biological Macromolecules, 72, 1191-1195 (2015).
32) S. Ifuku,* Y. Tsukiyama, T. Yukawa, M. Egusa, H. Kaminaka, H. Izawa, M. Morimoto, H. Saimoto “Facile preparation of silver nanoparticles immobilized
on chitin nanofiber surfaces to endow antifungal activities” Carbohydrate
Polymers, 117, 813-817 (2015).
31) A. K. Dutta, M. Egusa, H. Kaminaka, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku* “Facile preparation of surface N-halamine
chitin nanofiber to endow antibacterial and antifungal activities” Carbohydrate
Polymers, 115, 342-347 (2015).
30) A. K. Dutta, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku* “Novel preparation of chitin nanocrystals
by H2SO4 and H3PO4 hydrolysis followed by high-pressure water jet treatments”
Journal of Chitin and Chitosan Science, 2, 179-184 (2014).
29) S. Ifuku,* N. Suzuki, H. Izawa, M. Morimoto, H. Saimoto “Surface maleylation and naphthaloylation of
chitin nanofibers for property enhancement” Reactive & Functional Polymers,
85, 121-125 (2014).
28) S. Ifuku,* H. Maeta, H. Izawa, M. Morimoto, H. Saimoto “Facile preparation of aramid nanofibers from
Twaron fibers by a downsizing process” RSC Advances, 4, 40377-40380 (2014).
27) S. Ifuku,* N. Suzuki, H. Izawa, M. Morimoto, H. Saimoto “Surface phthaloylation of chitin nanofiber in
aqueous media to improve solubility in aromatic solvents and give thermo-responsive
and ultraviolet protection protperties” RSC Advances, 4, 19246-19250 (2014).
26) Y. Daimon,H. Izawa,* K. Kawakami*, P. Zywicki, H. Sakai, M. Abe, J. P. Hill, K. Ariga “Media-dependent
morphology of supramolecular aggregates of beta-cyclodextrin-grafted chitosan
and insulin through multivalent interactions”Journal of Materials Chemistry B, 2, 1802-1812 (2014).
25)H. Izawa,* S. Nishino, H. Maeda, K. Morita, S. Ifuku, M. Morimoto, H. Saimoto,
J. Kadokawa "Mineralization of hydroxyapatite upon a unique xanthan
gum hydrogel by an alternate soaking process" Carbohydrate Polymers,
102, 846–851 (2014).
24) M. Morimoto,* M. Takatori, T. Hayashi, D. Mori, O. Takashima, S. Yoshida,
K. Sato, H. Kawamoto, J. Tamura, H. Izawa, S. Ifuku, H. Saimoto “Depolymerization of sulfated polysaccharides under
hydrothermal conditions” Carbohydrate Research, 384, 56–60 (2014).
23) S. Ifuku,* A. Ikuta, M. Egusa, H. Kaminaka, H. Izawa, M. Morimoto, H. Saimoto “Preparation of high-strength transparent chitosan
film reinforced with surface-deacetylated chitin nanofibers” Carbohydrate
Polymers, 98, 1198-1202 (2013).
22) S. Ifuku,* K. Nakata, A. Ikuta, T. Oba, Z. Shervani, A. K. Dutta, H. Izawa, M. Morimoto, H. Saimoto “Preparation of chitin nanofiber-reinforced double-decker-shaped
polysilsesquioxane film” Journal of Chitin and Chitosan Science, 1, 21-25
(2013).
21) A. K. Dutta, K. Yamada, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku* “Preparation of Chitin Nanofibers
from Dry Chitin Powder by Star Burst System: Dependence on Number of Passes”
Journal of Chitin and Chitosan Science, 1, 59-64 (2013).
20) A. K. Dutta, N. Kawamoto, G. Sugino, H. Izawa, M. Morimoto, H. Saimoto, S. Ifuku* “Simple preparation of chitosan nanofibers
from dry chitosan powder by the Star Burst system” Carbohydrate Polymers,
97, 363-367 (2013).
19) Y. Kosaki,H. Izawa,* S. Ishihara*, K. Kawakami, M. Sumita, Y. Tateyama, Q. Ji, V. Krishnan,
S. Hishita, J. P. Hill, A. Vinu, S. Shiratori*, K. Ariga* “Nanoporous carbon
sensor with cage-in-fiber structure: highly-selective aniline adsorbent
towards cancer risk management” ACS Applied Materials & Interfaces,
5, 2930-2934 (2013).
18)H. Izawa, K. Kawakami,* M. Sumita, Y. Tateyama, J. P. Hill, K. Ariga* “beta-Cyclodextrin-crosslinked
alginate gel for patient-controlled drug delivery systems: regulation of
host–guest interactions with mechanical stimuli” Journal of Materials Chemistry
B, 1, 2155-2161 (2013). (Most read article; 3rd, 2013, March,)
17) Y. Takemoto, H. Izawa, Y. Umegatani, K. Yamamoto, A. Kubo, M. Yanase, T. Takaha, J. Kadokawa*
“Synthesis of highly branched anionic alpha-glucans by thermostable phosphorylase-catalyzed
alpha-glucuronylation” Carbohydrate Research, 366, 38-44 (2013).
16) Y. Umegatani, H. Izawa, M. Nawaji, K. Yamamoto, A. Kubo, M. Yanase, T. Takaha, J. Kadokawa* “Enzymatic
alpha-glucuronylation of maltooligosaccharides using alpha-glucuronic acid
1-phosphate as glycosyl donor catalyzed by a thermostable phosphorylase
from Aquifex aeolicus VF5” Carbohydrate Research, 350, 81-85 (2012).
15) J. Kadokawa,* H. Izawa, T. Ohta, S. Wakizono, K. Yamamoto “Photo-induced reduction reaction of
methylene blue in an ionic liquid” International Journal of Organic Chemistry,
1, 158-161 (2011).
14) S. Mine, K. Prasad, H. Izawa, K. Sonoda, J. Kadokawa* “Preparation of guar gum-based functional materials
using ionic liquid” Journal of Materials Chemistry, 20, 9220–9225 (2010).
13)H. Izawa, S. Wakizono, J. Kadokawa* “Fluorescence resonance-energy-transfer in
systems of Rhodamine 6G with ionic liquid showing emissions by excitation
at wide wavelength areas” Chemical Communications, 46, 6359-6361 (2010).
12)H. Izawa, J. Kadokawa* “Preparation and characterizations of functional ionic liquid-gel
and hydrogel materials of xanthan gum” Journal of Materials Chemistry,
20, 5235-5241 (2010).
11) S. Kawazoe, H. Izawa, M. Nawaji, Y. Kaneko, J. Kadokawa* “Phosphorylase-catalyzed N-formyl--glucosaminylation
of maltooligosaccharides” Carbohydrate Research, 345, 631-636 (2010).
10)H. Izawa, M. Nawaji, Y. Kaneko, J. Kadokawa* “Preparation of glycogen-based polysaccharide
materials by phosphorylase-catalyzed chain-elongation of glycogen” Macromolecular
Bioscience, 9, 1098-1104 (2009).
9)H. Izawa, Y. Kaneko, J. Kadokawa “Unique gel of xanthan gum with ionic liquid and
its conversion into high performance hydrogel” Journal of Materials Chemistry,
19, 6969-6972 (2009).
8) S. Mine, H. Izawa, Y. Kaneko, J. Kadokawa* “Acetylation of -chitin in ionic liquids” Carbohydrate
Research, 344, 2263-2265 (2009).
7) K, Prasad, H. Izawa, Y. Kaneko, J. Kadokawa* “Preparation of temperature-induced shapeable
film material from guar gum-based gel with an ionic liquid” Journal of
Materials Chemistry, 19, 4088-4090 (2009).
6)H. Izawa, Y. Kaneko, and J. Kadokawa* “Apparent production of enzymatically synthesized
amylose in DMSO by means of calcium alginate hydrogel beads/DMSO System”
Journal of Carbohydrate Chemistry, 28, 179-190 (2009).
5) M. Nawaji, H. Izawa, Y. Kaneko, J. Kadokawa* “Enzymatic alpha-glucosaminylation of maltooligosaccharides
catalyzed by phosphorylase” Carbohydrate Research, 343, 2692-2696 (2008).
4) M. Nawaji, H. Izawa, Y. Kaneko, J. Kadokawa* “Enzymatic synthesis of alpha-D-xylosylated maltooligosaccharides
by phosphorylase-catalyzed xylosylation” Journal of Carbohydrate Chemistry,
27, 214-222 (2008).
3) H. Kuroda,* H. Izawa “Synthesis and triethylamine-catalyzed cyclization reaction of 4-pentyne-1,3-diones
system having various substituents” Chinese Journal of Chemistry, 26, 1944-1947
(2008).
2) H. Kuroda,* H. Izawa “Synthesis and acid- or base- catalyzed cyclization of various 4-pentyne-1,3-dione
derivatives” Bulletin of the Chemical Society of Japan, 80, 780-782 (2007).
1) H. Kuroda,* E. Hanaki, H. Izawa, M. Kano, H. Itahashi “A convenient method for the preparation of alpha-vinylfurans
by phosphine-initiated reactions of various substituted enynes bearing
a carbonyl group with aldehydes” Tetrahedron, 60, 1913-1920 (2004).
総説
7) 井澤浩則 “キトサンを用いて微細構造を創製する新規アプローチの開拓”, キチン・キトサン研究, 1, 45-51 (2019).
6)H. Izawa* “Preparation of bio-based wrinkled surfaces via lignification mimetic
reactions and drying: A new approach to develop surface wrinkling” Polymer
Journal, 49, 759–765 (2017).(Selected as Cover)
5)H. Izawa,* Y. Haraya, K. Kawakami, “Cyclodextrin-grafted chitosans for pharmaceutical
applications” Trends in Glycoscience and Glycotechnology, 29, E953–E958
(2017).
4) K. Kawakami, M. Ebara, H. Izawa, N. M. Sanchez-Ballester, J. P. Hill,
K. Ariga, “Supramolecular approaches for drug development” Current Medicinal
Chemistry., 19, 2388-2398 (2012).
3) K. Ariga, S. Ishihara, H. Izawa, H. Xia, J. Hill, “Operation of micro and molecular machines: a new concept
with its origins in interface science” Physical Chemistry Chemical Physics,
13, 4802-4811 (2011).
2) K. Ariga, G. J. Richards, S. Ishihara, H. Izawa, J. P. Hill, “Intelligent chiral sensing based on supramolecular and interfacial
concepts” Sensors, 10, 6796-6820 (2010).
1) 石原伸輔, 井澤浩則, 有賀克彦, “不斉（キラル）認識の新たな展開：界面・超分子現象によるトリック”, 表面, 48, 21-28 (2010).
記事など
6) 井澤浩則 “樹木細胞壁を模倣したスキン層が誘起するバイオベースリンクル表面” 塗装工学、Vol. 52、No 8、4-8 (2017）.
5) 井澤浩則 “Hot Topic樹木細胞壁を模倣したバイオベースリンクル表面” 日本化学会 化学と工業、Vol. 70-8, 690 (2017).
4) 井澤浩則 “天然資源と酵素反応のみから調製されるバイオベースリンクル表面” 化学工業、68巻、2017年
3) 井澤浩則 ”キチンをほぐす科学の今昔” 化学と教育、64巻、184-187、2016年.
2) 井澤浩則 ”応用展開に向けた”鳥取発”キチン・キトサン研究の動向”、化学と工業、68-3, 264-265 (2015).
1) 井澤浩則、川上亘作、有賀克彦 “物理刺激で薬物を放出するゲル担体を利用した患者制御型ドラッグデリバリーシステム” Drug Delivery System、DDS学会、28
巻、92-98、2013年.
著書
2) K. Ariga, G. J. Richards, M. Akamatsu, H. Izawa, J. P. Hill, 『Supramolecular Materials Nanoarchitectonics』 in MANIPULATION
OF NANOSCALE MATERIALS: AN INTRODUCTION TO NANOARCHITECTONICS, Ed. by K.
Ariga, RSC book chapter (2012).
1) H. Izawa, J. Kadokawa,『Preparation of Functional Amylosic Materials by Phosphorylase-catalyzed
Polymerization』 in Interfacial Researches in Fundamental and Material Science
of Oligo- and Polysaccharides, Ed. by J. Kadokawa, Transworld Research
Network, Trivandrum, Chapter 4 (2010).